Publications

2020

2019

2018

2017

2016

2015

2013

2012

2011

2010

2009

2008

2007

2006

2004

2003

2002

2001

2000

1999

1998

Journal Articles

Delayed-type hypersensitivity skin test against Neospora caninum in heifers with undetectable specific antibodies

Comparative Immunology, Microbiology and Infectious Diseases Volume 72, October 2020

Fiorani F., Hecker Y.P., Cirone K.M., Armendano J.I. Gual I., Campero L.M., Wilkowsky S.E., Cobo E. R., Corva P.M., Morrell E.L., Cantón G.J., Moore D.P.

Science Direct https://doi.org/10.1016/j.cimid.2020.101522

Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production.

Gut Microbes. 13 July 2020

Ravi Holani, Anshu Babbar, Graham A. D. Blyth, Fernando Lopes, Humberto Jijon, Derek M. McKay, Morley D. Hollenberg & Eduardo R. Cobo 

Taylor & Francis Online published Open Access.

The Network of Colonic Host Defense Peptides as an Innate Immune Defense Against Enteropathogenic Bacteria.

Frontiers Immunology. 20 May 2020 

Graham A. D. Blyth, Liam Connors, Cristina Fodor and Eduardo R. Cobo (2020)

Frontier Immunology

Cathelicidins mitigate Staphylococcus aureus mastitis and reduce bacterial invasion in murine mammary epithelium.

Infection and Immunity. 2020 Apr 27. pii: IAI.00230-20. doi: 10.1128/IAI.00230-20.

Cavalcante PA, Knight CG, Tan YL, Monteiro APA, Barkema HW, Cobo ER (2020)

PMID: 32341117

Klebsiella pneumoniae isolated from bovine mastitis is cytopathogenic for bovine mammary epithelial cells. 

J Dairy Science. Feb 6. pii: S0022-0302(20)30086-2. doi: 10.3168/jds.2019-17458. 

Cheng J, Zhang J, Han B, Barkema HW, Cobo ER, Kastelic JP, Zhou M, Shi Y, Wang J, Yang R, Gao J (2020)

PMID: 32037181

 

Prototheca zopfii genotype II induces mitochondrial apoptosis in models of bovine mastitis. 

Sci Rep. 10(1):698. doi: 10.1038/s41598-020-57645-z. 

Shahid M, Cobo ER, Chen L, Cavalcante PA, Barkema HW, Gao J, Xu S, Liu Y, Knight CG, Kastelic JP, Han B (2020)

PMID: 31959834

Synthetic cathelicidin LL-37 reduces Mycobacterium avium subsp. paratuberculosis internalization and pro-inflammatory cytokines in macrophages. 

Cell Tissue Res. 2020 Jan; 379(1):207-217. doi: 10.1007/s00441-019-03098-4. Epub 2019 Sep 2. 

Cirone KM, Lahiri P, Holani R, Tan YL, Arrazuria R, De Buck J, Barkema HW, Cobo ER (2020)

PMID: 31478135

 

Oxytetracycline reduces inflammation and treponeme burden whereas vitamin D3 promotes β-defensin expression in bovine infectious digital dermatitis. 

Cell Tissue Res. 2020 Feb; 379(2):337-348. doi: 10.1007/s00441-019-03082-y. Epub 2019 Aug 13. 

Watts KM, Lahiri P, Arrazuria R, De Buck J, Knight CG, Orsel K, Barkema HW, Cobo ER (2020)

PMID: 31410630

Adherent/invasive capacities of bovine-associated Aerococcus viridans contribute to pathogenesis of acute mastitis in a murine model. 

Vet Microbiol. 2019 Mar; 230:202-211. doi: 10.1016/j.vetmic.2019.02.016. Epub 2019 Feb 8. 

Liu G, Yin J, Han B, Barkema HW, Shahid M, De Buck J, Cobo ER, Kastelic JP, Gao J (2019)

PMID: 30827389

 

Human cathelicidin improves colonic epithelial defenses against Salmonella typhimurium by modulating bacterial invasion, TLR4 and pro-inflammatory cytokines. 

Cell Tissue Res. 2019 Jun; 376(3):433-442. doi: 10.1007/s00441-018-02984-7. Epub 2019 Feb 20. 

Marin M, Holani R, Blyth GAD, Drouin D, Odeón A, Cobo ER (2019)

PMID: 30788579

 

Molecular epidemiology and distribution of antimicrobial resistance genes of Staphylococcus species isolated from Chinese dairy cows with clinical mastitis. 

J Dairy Sci. 2019 Feb; 102(2):1571-1583. doi: 10.3168/jds.2018-15136. Epub 2018 Dec 24. 

Qu Y, Zhao H, Nobrega DB, Cobo ER, Han B, Zhao Z, Li S, Li M, Barkema HW, Gao J (2019)

PMID: 30591326

 

Correction for Cobo et al., "Entamoeba histolytica Alters Ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency". 

Infect Immun. 2018 Sep 21; 86(10). pii: e00564-18. doi: 10.1128/IAI.00564-18. 

Cobo ER, Holani R, Moreau F, Nakamura K, Ayabe T, Mastroianni JR, Eriguchi Y, Ouellette A, Chadee K (2018)

PMID: 30242014

 

A Differential Innate Immune Response in Active and Chronic Stages of Bovine Infectious Digital Dermatitis. 

Front Microbiol. 2018 Jul 19; 9:1586. doi: 10.3389/fmicb.2018.01586. eCollection 2018. 

Watts KM, Fodor C, Beninger C, Lahiri P, Arrazuria R, De Buck J, Knight CG, Orsel K, Barkema HW, Cobo ER (2018)

PMID: 30072966

 

Entamoeba histolytica alters ileal Paneth cell functions in intact and Muc2 mucin deficiency. 

Infection and Immunity (IAI00208-18). “Spotlight” as research article of significant interest from the current issue. 

Cobo ER., Holani R, Moreau F, Nakamura K, Ayabe T, Mastroianni J, Ouellette A, Chadee K (2018)

PMID: 29685982

 

Host defense cathelicidins in cattle: types, production, bioactive functions and potential therapeutic and diagnostic applications. 

International Journal Antimicrobial Agents, pii: S0924-8579(18)30044-X. doi: 10.1016/j.ijantimicag.2018.02.006. 

Young-Speirs M., Drouin D., Cavalcante P.A., Barkema H.W., Cobo ER (2018)

PMID: 29476808

 

Cathelicidin modulates synthesis of Toll-like receptors (TLRs) 4 and 9 in colonic epithelium. 

Molecular Immunology Oct 4; 91: 249-258. doi: 10.1016. 

Marin M.; Holani R.; Shah C.B.; Odeon A.; Cobo E.R. (2017)

PMID: 28988039

 

Toll-like receptors 3, 7 and 8 are upregulated in the placental caruncle and fetal spleen of Nesopora caninum experimentally infected cattle. 

Veterinary Parasitology, Mar 15; 236:58-61. doi: 10.1016. 

Marin M.; Hecker Y.; Quintana S.; Perez S.; Leunda M.; Canton G.; Cobo E.R.; Moore D.; Odeon A. (2017)

PMID: 28288766

 

MUC2 mucin and butyrate contribute to the synthesis of the antimicrobial peptide cathelicidin in response to Entamoeba histolytica and dextran sodium sulfate- induced colitis. 

Infection and Immunity,  23;85(3). pii: e00905-16. doi: 10.1128/IAI.00905-16. 

Cobo E.R.; Kissoon-Singh V.; Moreau, F.; Holani R.; Chadee K. (2017)

PMID: 28069814

 

Proline-arginine rich (PR-39) cathelicidin: Structure, expression and functional implication in intestinal health. 

Comparative Immunology Microbiology Infectious Diseases, 49: 95-101. 

Holani R.; Shah C.; Haji Q., Inglis G.D., Uwiera R.R.; Cobo E.R. (2016)

PMID: 27865272

 

A review of sexually transmitted bovine trichomoniasis and campylobacteriosis affecting cattle reproductive health. 

Theriogenology 85 (5): 781-91. 

Michi A, Favetto H, Kastelic J, Cobo E. (2016)

PMID: 26679515

 

Colonic MUC2 mucin regulates the expression and antimicrobial activity of defensin 2. 

Mucosal Immunology 8(16): 1360-72.2. 

Cobo E, Kissoon-Singh V, Moreau F, Chadee K. (2015)

PMID: 25921338

 

Expanded therapeutic potential in broad activity space of structurally diverse next-generation 5- nitroimidazole antimicrobials. 

Proceeding of the National Academy of Sciences of the United States of America (PNAS) 110(43): 17564-17569. 

Miyamoto Y, Kalisiak J, Korthals K, Tineke S, Young Cheung D, Lozano R, Cobo E, Upcroft P, Upcroft J, Gillin F, Fokin V, Sharpless B, Eckmann L. (2013).

PMID: 24101497

 

Antimicrobial human defensins in the colon and their role in infectious and non-infectious diseases. 

Pathogens 2(1): 177-192. 

Cobo E, Chadee K. (2013)

PMID: 25436887

 

A high throughput drug screen for Entamoeba histolytica identifies a new lead and target. 

Nature Medicine 18(6): 956-960. 

Debnath A, Parsonage D, Andrade R, He C, Cobo E, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez M, Gunatilleke S, Barrios A, Arkin M, Poole L, McKerrow J, Reed S. (2012)

PMID: 22610278

 

Effect of vinyl sulfone inhibitors of cysteine proteinases on Tritrichomonas foetus infection. 

International Journal of Antimicrobial Agents 39(3): 259-262. 

Cobo E, Reed S, Corbeil L. (2012)

PMID: 22104282

 

Entamoeba histolytica induces intestinal cathelicidins but is resistant to cathelicidin-mediated killing. 

Infection and Immunity 80(1): 143-149. 

Cobo E, He C, Hirata K, Hwang G, Tran U, Eckmann L, Gallo R, Reed S. (2012)

PMID: 22083705

 

Murine models of vaginal trichomonad infections. 

American Journal of Tropical Medicine and Hygiene 85(4): 667-673. 

Cobo E, Eckmann L, Corbeil L. (2011)

PMID: 21976570

 

Immunity to infections in the lower genital tract of bulls. 

Journal of Reproductive Immunology 89(1): 55-61. 

Cobo E, Corbeil L, BonDurant R. (2011)

PMID: 21474188

 

A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. 

Journal of Biological Chemistry 285(24): 18516-18527. 

He C, Nora G, Scheider E, Kerr I, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd S, Hruz P, Cobo E, Le C, Liu W, Eckmann L, Dorrestein P, Houpt E, Brinen L, Craik C, Roush W, McKerrow J, Reed S. (2010)

PMID: 20378535

 

Preputial cellular and antibody responses of bulls vaccinated and/or challenged with Tritrichomonas foetus. 

Vaccine 11(28): 361-370. 

Cobo E, Corbeil L, Gerswhin L, BonDurant R. (2009)

PMID: 19879225

 

Comparative histopathology and antibody responses in virgin heifers experimentally infected with non-Tritrichomonas foetus trichomonads or Tritrichomonas foetus. 

Veterinary Parasitology 151, 2-4: 170-180. 

Agnew D.; Munson L.; Cobo E.R.; Olesen D.; Corbeil L.; BonDurant R. (2008)

PMID: 18078717

 

Tetratrichomonas spp. and Pentatrichomonas hominis are not persistently detectable after intravaginal inoculation of estrous heifers. 

Veterinary Parasitology 150, 1-2: 18-26. 

Cobo E.R.; Corbeil L.; Agnew D.; VanHoosear K.; Friend A.; Olesen D.; BonDurant R. (2007)

PMID: 17950533

 

Sensitivity and specificity of culture and PCR applied directly on smegma samples of bulls for testing of Tritrichomonas foetus. 

Theriogenology 68, 6: 853-860. 

Cobo E.R.; Favetto P.; Lane V.; Friend A.; VanHoosear K.; Mitchell J.; BonDurant R. (2007)

PMID: 17681370

 

Bayesian estimation of Tritrichomonas foetus diagnostic test sensitivity and specificity in range beef bulls. 

Veterinary Parasitology 142, 1-2: 159-162. 

Perez A.; Cobo E.R.; Martinez A.; Campero C.; Spath E. (2006)

PMID: 16876951

 

Tritrichomonas foetus: patogénesis de la mortalidad embrionaria/fetal, caracterización de antígenos vacunales y respuesta inmune inducida. 

Revista de Medicina Veterinaria 87: 47-56.

Campero C.; Cobo E.R. (2006)

 

Immunization in heifers with dual vaccines containing Tritrichomonas foetus and Campylobacter fetus antigens using systemic and mucosal routes. 

Theriogenology 62, 8: 1367-1382. 

Cobo E.R.; Morsella C.; Cano D.; Cipolla A.; Campero C. (2004)

PMID: 15451246

 

Lectin binding pattern and immunohistochemical antigen detection in the genitalia of Tritrichomonas foetus-infected heifers. 

Journal of Comparative Pathology 131, 2-3: 127-134. 

Cobo E.R.; Campero, C.; Gimeno E.; Barbeito C. (2004)

PMID: 15276852

 

Failure to establish infection with Tetratrichomonads spp. in the reproductive tracts of heifers and bulls. 

Veterinary Parasitology 120: 145-150. 

Cobo E.R.; Canton G.; Morrell E.; Cano D.; Campero C. (2004)

PMID: 15019152

 

Ultrastructural study of a tetratrichomonad species isolated from preputial smegma of virgin bulls. 

Veterinary Parasitology 117: 195-211. 

Cobo E.R.; Campero C.; Mariante R.; Benchimol M. (2003)

PMID: 14630428

 

Effect of two commercial vaccines to Campylobacter fetus subspecies on heifers naturally challenged. 

Journal Veterinary Medicine 50, 2: 75-80. 

Cobo E.R.; Cipolla A.; Morsella C.; Cano D.; Campero C. (2003)

PMID: 12675898

 

Two-step (culture and PCR) diagnostic approach for differentiation of non-T. foetus trichomonads from genitalia of virgin beef bulls in Argentina. 

Veterinary Parasitology 112, 3: 167-175. 

Campero C.; Rodriguez Dubra C.; Bolondi A.; Cacciato C.; Cobo E.R.; Perez S.; Odeon A.; Cipolla A.; BonDurant R. (2003)

PMID: 12591192

 

Heifers immunized with whole-cell and membrane vaccines against Tritrichomonas foetus and naturally challenged with an infected bull. 

Veterinary Parasitology 109: 169-184. 

Cobo E.R.; Cano D.; Rossetti O.; Campero C. (2002)

PMID: 12423930

Nuevos aspectos inmunológicos y vacunales de la tricomoniasis bovina.

Revista de Medicina Veterinaria 83, 5: 203-208.

Cobo E.R.; Campero C. (2002)

Experimental infection with Tritrichomonas suis in heifers. 

Veterinary Parasitology 99, 1: 73-78. 

Cobo E.R., Cano D.; Campero C. (2001)

PMID: 11445157

 

Riesgo y control de Campylobacter fetus en el semen bovino usado para inseminación artificial en Argentina. 

Therios 29, 153: 102-107.

Cobo E.R. (2000)

 

Aislamiento de Brucella ovis del semen de carneros seropositivos a la prueba de ELISA y con clínica genital normal. 

Revista Argentina de Microbiología 31, 1: 40-43. 

Paolicchi F.; Cipolla A.; Vagnoni L.; Cobo E.R.; Vagnozzi A; Ramondino R.; Silva Paulo P.; Vigliocco A. (1999)

PMID: 10509410

 

Reporte de dos casos de feocromocitoma en ovejas adultas. 

Veterinaria Argentina 143: 180-183.

Campero C.; Cobo E.R.; Vagnoni L.; Vagnozzi A. (1998).

 

Book Chapters

Antimicrobial peptides in gastrointestinal disease.

Chapter 7:"Host defense peptides as innate immunomodulators in the pathogenesis of colitis".

Elsevier B978-0-12-814319.

Holani R, Marin M, Kastelic J, Cobo ER (2018)

Frontiers in Parasitology (Volume 2). Water-borne protozoa in humans.

Chapter 5: Entamoeba histolytica and other pathogenic intestinal amoebae: 103-123. ISBN: 978-1-68108-434-3, ISSN: 2542-4211. Edited by Fabrizio Bruschi (Univ. di Pisa, Italy). Published by Bentham Science Publishers, Sharjah, United Arab Emirates.

Cobo ER; Chadee K (2017)

Contact

Email: ecobo@ucalgary.ca

Phone: (403) 210-7247

  • Instagram
  • LinkedIn

© 2020 by Yi Lin Tan, MSc. Proudly created with Wix.com