Every innate immune reaction is a lesson on how to survive infections without dying in the attempt
Publications
2025
2020
2015
2010
2000
Journal Articles
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Immunoregulatory and antiviral effect mediated by TLR7 and BMAP28 interaction in bovine alphaherpesvirus-infected respiratory primary cultures
Veterinary Microbiology, 2025
Burucúa M, Risalde MA, Langellotti CA, Quintana S, Odeón AC, Cobo ER, Cutrera AP, Pérez SE, Marin MS
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In silico integrative scRNA analysis of human colonic epithelium indicates four Tuft cell subtypes
American Journal Physiology Gastrointestinal Liver Physiology, 2024
Herik A, Sinha S, Arora R, Small C, Dufour A, Biernaskie J, Cobo ER, McKay D
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Breed variability in the cellular mediated immune response to experimental Neospora caninum infection in heifers
Veterinary Immunology Immunopathology, 2024
Fiorani F, Dallard B, Cheuquepan FA, Sosa E, Pardo AM, Gual I, Morrell EL, Marin MS, Quintana S, Canton GJ, Valentini BS, Echaide IE, Torioni SM, Cobo ER, Corva PM, Moore DP
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Proinflammatory CD14highCD16low monocytes/macrophages prevail in Treponema phagedenis- associated bovine digital dermatitisrole of cathelicidins in neutrophil biology
Infection Immunity, 2024
Lahiri P, Arrazuria R, Tan YL, De Buck J, Hollenberg MD, Orsel K, Cobo ER
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The role of cathelicidins in neutrophil biology
Journal of Leukocyte Biology, 2024
Yoon G, Puentes R, Tran J, Multani A, Cobo ER
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Fosfomycin mitigated apoptosis while increased mucin secretion in swine intestinal explants challenged by Lawsonia intracellularis
Pharmacological Research, 2024
Perez Gaudio DS, Fodor C, Decundo JM, Martinez G, Mozo J, Eguia V, Dieguez SN, Soraci AL, Cobo ER.
PMID:
Antioxidative Sirt1 and the Keap1-Nrf2 signaling pathway impair inflammation and positively regulate autophagy in murine mammary epithelial cells or mammary glands infected with Streptococcus uberis
Antioxidants (Basel), 2024​
Khan S, Wang T, Cobo ER, Liang B, Khan MA, Xu M, Qu W, Gao J, Barkema HW, Kastelic JP, Liu G, Bo H.
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Heme oxygenase activates calcium release from the endoplasmic reticulum of bovine mammary epithelial cells to promote TFEB entry into the nucleus to reduce the intracellular load of Mycoplasma bovis
Microbiological Research, 2024
Xu M, Zhu Z, Meng S, Li H, Wang A, Barkema HW, Cobo ER, Kastelic JP, Khan MA, Gao J, Bo H.
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Streptococcus uberis induced expressions of pro-inflammatory IL-6, TNF-α, and IFN-γ in bovine mammary epithelial cells associated with inhibited autophagy and autophagy flux formation
Microbial Pathogenesis, 2023
Khan S, Yang J, Cobo ER, Wang Y, Xu M, Wang T, Shi Y, Liu G, Han B
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Host innate immune responses and microbiome profile of neonatal calves challenged with Cryptosporidium parvum and the effect of bovine colostrum supplementation
Frontiers in Cellular and Infection Microbiology, 2023
Gamsjäger L, Cirone KM, Schluessel S, Campsall M, Herik A, Lahiri P, Young D, Dufour A, Sapountzis P, Otani S, Gomez DE, Windeyer MC, Cobo ER
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Colonic innate immune defenses and microbiota alterations in acute swine dysentery
Microbial Pathogenesis, 2022
Fodor CC, Fouhse J, Drouin D, Ma T, Willing BP, Guan LL, Cobo ER
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Assessment of microRNA profiles in small extracellular vesicles isolated from bovine colostrum with different immunoglobulin G concentrations
Journal Dairy Science (JDS) Communication, 2022
Ma T, Li W, Chen Y, Cobo ER, Windeyer C, Gamsjäger L, Diao Q, Tu Y, Guan LL
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Cathelicidins induce Toll-Interacting protein synthesis to prevent apoptosis in colonic epithelium
Journal of Innate Immunity , 2022
Holani R, Rathnayaka C, Blyth GAD, Babbar A, Lahiri P, Young D, Dufour A, Hollenberg MD, McKay DM, Cobo ER
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Interleukin-4 programmed macrophages suppress colitis and do not enhance infectious-colitis, ionflammation-associated colon cancer or airway hypersensitivity epithelium
Frontiers in Immunology, 2021
Callejas BE, Blyth GAD, Jendzjowsky N, Wang A, Babbar A, Koro K, Wilson RJA, Kelly MM, Cobo ER, McKay DM
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Systemic murine cathelicidin CRAMP safely attenuated colonic neutrophil infiltration in pigs
Veterinary Immunology Immunopathology, 2022
Fodor CC, McCorkell R, Muench G, Cobo ER
PMID: 35640361
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Sequence edition of single domains modulates the final immune and antimicrobial potential of a new generation of multidomain recombinant proteins
Scientific Report, 2021
Roca-Pinilla R, Holani R, López-Cano A, Saubi C, Baltà-Foix R, Cobo ER, Garcia-Fruitós E, Arís A
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Effects of different culture media on growth of Treponema spp. isolated from digital dermatitis
Anaerobe, 2021
Arrazuria R, Caddey B, Cobo ER, Barkema HW, De Buck J
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Peritoneal macrophages are impaired in cathelicidin-deficient mice systemically challenged with Escherichia coli
Cell and Tissue Research, 2021
Boucher E, Brown L, Lahiri P, Cobo ER
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Early immune innate hallmarks and microbiome changes across the gut during Escherichia coli O157: H7 infection in cattle
Scientific Reports, 2020
Larzábal M, Marques Da Silva W, Multani A, Vagnoni LE, Moore DP, Marin MS, Riviere NA, Delgado FO, Vilte DA, Romero Victorica M, Ma T, Guan LL, Talia P, Cataldi A, Cobo ER.
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Treponema spp. isolated from bovine digital dermatitis display different pathogenicity in a murine abscess model
Microorganisms​, 2020
Arrazuria R, Knight CG, Lahiri P, Cobo ER, Barkema HW, De Buck J
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Delayed-type hypersensitivity skin test against Neospora caninum in heifers with undetectable specific antibodies
Comparative Immunology, Microbiology and Infectious Diseases, 2020
Fiorani F, Hecker YP, Cirone KM, Armendano JI, Gual I, Campero LM, Wilkowsky SE, Cobo ER, Corva PM, Morrell EL, Cantón GJ, Moore DP
PMID: 32739729
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Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production
Gut Microbes, 2020
Holani R, Babbar A, Blyth GAD, Lopes F, Jijon H, McKay DM, Hollenberg MD, Cobo ER
PMID: 32658599
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The network of colonic host defense peptides as an innate immune defense against enteropathogenic bacteria
Frontiers in Immunology, 2020
Blyth GAD, Connors L, Fodor CC, Cobo ER
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Cathelicidins mitigate Staphylococcus aureus mastitis and reduce bacterial invasion in murine mammary epithelium
Infection and Immunity, 2020
Cavalcante PA, Knight CG, Tan YL, Monteiro APA, Barkema HW, Cobo ER
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Klebsiella pneumoniae isolated from bovine mastitis is cytopathogenic for bovine mammary epithelial cells
Journal Dairy Science, 2020
Cheng J, Zhang J, Han B, Barkema HW, Cobo ER, Kastelic JP, Zhou M, Shi Y, Wang J, Yang R, Gao J
Prototheca zopfii genotype II induces mitochondrial apoptosis in models of bovine mastitis
Scientific Reports, 2020
Shahid M, Cobo ER, Chen L, Cavalcante PA, Barkema HW, Gao J, Xu S, Liu Y, Knight CG, Kastelic JP, Han B
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Synthetic cathelicidin LL-37 reduces Mycobacterium avium subsp. paratuberculosis internalization and pro-inflammatory cytokines in macrophages
Cell Tissue Research, 2020
Cirone KM, Lahiri P, Holani R, Tan YL, Arrazuria R, De Buck J, Barkema HW, Cobo ER
Oxytetracycline reduces inflammation and treponeme burden whereas vitamin D3 promotes β-defensin expression in bovine infectious digital dermatitis
Cell Tissue Research, 2020
Watts KM, Lahiri P, Arrazuria R, De Buck J, Knight CG, Orsel K, Barkema HW, Cobo ER
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Adherent/invasive capacities of bovine-associated Aerococcus viridans contribute to pathogenesis of acute mastitis in a murine model
Veterinary Microbiology, 2019
Liu G, Yin J, Han B, Barkema HW, Shahid M, De Buck J, Cobo ER, Kastelic JP, Gao J
Human cathelicidin improves colonic epithelial defenses against Salmonella typhimurium by modulating bacterial invasion, TLR4 and pro-inflammatory cytokines
Cell Tissue Research, 2019
Marin M, Holani R, Blyth GAD, Drouin D, Odeón A, Cobo ER
Molecular epidemiology and distribution of antimicrobial resistance genes of Staphylococcus species isolated from Chinese dairy cows with clinical mastitis
Journal Dairy Science, 2019
Qu Y, Zhao H, Nobrega DB, Cobo ER, Han B, Zhao Z, Li S, Li M, Barkema HW, Gao J
Preputial cellular and antibody responses of bulls vaccinated and/or challenged with Tritrichomonas foetus
Vaccine, 2019
Cobo ER, Corbeil L, Gerswhin L, BonDurant R
Comparative histopathology and antibody responses in virgin heifers experimentally infected with non-Tritrichomonas foetus trichomonads or Tritrichomonas foetus
Veterinary Parasitology, 2018
Agnew D, Munson L, Cobo ER, Olesen D, Corbeil L, BonDurant R
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A differential innate immune response in active and chronic stages of bovine infectious digital dermatitis
Frontiers in Microbiolology, 2018
Watts KM, Fodor C, Beninger C, Lahiri P, Arrazuria R, De Buck J, Knight CG, Orsel K, Barkema HW, Cobo ER
Entamoeba histolytica alters ileal Paneth cell functions in intact and Muc2 mucin deficiency
Infection and Immunity, 2018. “Spotlight” as research article of significant interest from the current issue.
Cobo ER, Holani R, Moreau F, Nakamura K, Ayabe T, Mastroianni J, Ouellette A, Chadee K
Host defense cathelicidins in cattle: types, production, bioactive functions and potential therapeutic and diagnostic applications
International Journal Antimicrobial Agents, 2018
Young-Speirs M, Drouin D, Cavalcante PA, Barkema HW, Cobo ER
Cathelicidin modulates synthesis of Toll-like receptors (TLRs) 4 and 9 in colonic epithelium
Molecular Immunology, 2017
Marin M, Holani R, Shah CB, Odeon A, Cobo ER
Toll-like receptors 3, 7 and 8 are upregulated in the placental caruncle and fetal spleen of Nesopora caninum experimentally infected cattle
Veterinary Parasitology, 2017
Marin M, Hecker Y, Quintana S, Perez S, Leunda M, Canton G, Cobo ER, Moore D, Odeon A
MUC2 mucin and butyrate contribute to the synthesis of the antimicrobial peptide cathelicidin in response to Entamoeba histolytica and dextran sodium sulfate- induced colitis
Infection Immunity, 2017
Cobo ER, Kissoon-Singh V, Moreau F, Holani R, Chadee K
Proline-arginine rich (PR-39) cathelicidin: Structure, expression and functional implication in intestinal health
Comparative Immunology Microbiology Infectious Diseases, 2016
Holani R, Shah C, Haji Q, Inglis GD, Uwiera RR, Cobo ER
A review of sexually transmitted bovine trichomoniasis and campylobacteriosis affecting cattle reproductive health
Theriogenology, 2016
Michi A, Favetto H, Kastelic J, Cobo ER
Colonic MUC2 mucin regulates the expression and antimicrobial activity of β-defensin 2
Mucosal Immunology, 2015
Cobo E, Kissoon-Singh V, Moreau F, Chadee K
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Tetratrichomonas spp. and Pentatrichomonas hominis are not persistently detectable after intravaginal inoculation of estrous heifers
Veterinary Parasitology, 2015
Cobo ER, Corbeil L, Agnew D, VanHoosear K, Friend A, Olesen D, BonDurant R
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Expanded therapeutic potential in broad activity space of structurally diverse next-generation 5- nitroimidazole antimicrobials
Proceeding of the National Academy of Sciences of the United States of America (PNAS), 2013
Miyamoto Y, Kalisiak J, Korthals K, Tineke S, Young Cheung D, Lozano R, Cobo ER, Upcroft P, Upcroft J, Gillin F, Fokin V, Sharpless B, Eckmann L
Antimicrobial human defensins in the colon and their role in infectious and non-infectious diseases
Pathogens, 2013
Cobo ER, Chadee K
A high throughput drug screen for Entamoeba histolytica identifies a new lead and target
Nature Medicine, 2012
Debnath A, Parsonage D, Andrade R, He C, Cobo ER, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez M, Gunatilleke S, Barrios A, Arkin M, Poole L, McKerrow J, Reed S
Effect of vinyl sulfone inhibitors of cysteine proteinases on Tritrichomonas foetus infection
International Journal of Antimicrobial Agents, 2012
Cobo ER, Reed S, Corbeil L
Entamoeba histolytica induces intestinal cathelicidins but is resistant to cathelicidin-mediated killing
Infection Immunity, 2012
Cobo ER, He C, Hirata K, Hwang G, Tran U, Eckmann L, Gallo R, Reed S
Murine models of vaginal trichomonad infections
American Journal of Tropical Medicine and Hygiene, 2011
Cobo ER, Eckmann L, Corbeil L
Immunity to infections in the lower genital tract of bulls
Journal of Reproductive Immunology, 2011
Cobo ER, Corbeil L, BonDurant R
A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target
Journal of Biological Chemistry, 2010
He C, Nora G, Scheider E, Kerr I, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd S, Hruz P, Cobo E, Le C, Liu W, Eckmann L, Dorrestein P, Houpt E, Brinen L, Craik C, Roush W, McKerrow J, Reed S
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Sensitivity and specificity of culture and PCR applied directly on smegma samples of bulls for testing of Tritrichomonas foetus
Theriogenology, 2007
Cobo ER, Favetto P, Lane V, Friend A, VanHoosear K, Mitchell J, BonDurant R
Bayesian estimation of Tritrichomonas foetus diagnostic test sensitivity and specificity in range beef bulls
Veterinary Parasitology, 2006
Perez A, Cobo ER, Martinez A, Campero C, Spath E
Tritrichomonas foetus: patogénesis de la mortalidad embrionaria/fetal, caracterización de antígenos vacunales y respuesta inmune inducida
Revista de Medicina Veterinaria, 2006
Campero C, Cobo ER
Immunization in heifers with dual vaccines containing Tritrichomonas foetus and Campylobacter fetus antigens using systemic and mucosal routes
Theriogenology, 2004
Cobo ER, Morsella C, Cano D, Cipolla A, Campero C
Lectin binding pattern and immunohistochemical antigen detection in the genitalia of Tritrichomonas foetus-infected heifers
Journal of Comparative Pathology, 2004
Cobo ER, Campero C, Gimeno E, Barbeito C
Failure to establish infection with Tetratrichomonads spp. in the reproductive tracts of heifers and bulls
Veterinary Parasitology, 2004
Cobo ER, Canton G, Morrell E, Cano D, Campero C
Ultrastructural study of a tetratrichomonad species isolated from preputial smegma of virgin bulls
Veterinary Parasitology, 2003
Cobo ER, Campero C, Mariante R, Benchimol M
Effect of two commercial vaccines to Campylobacter fetus subspecies on heifers naturally challenged
Journal Veterinary Medicine, 2003
Cobo ER, Cipolla A, Morsella C, Cano D, Campero C
Two-step (culture and PCR) diagnostic approach for differentiation of non-T. foetus trichomonads from genitalia of virgin beef bulls in Argentina
Veterinary Parasitology, 2003
Campero C, Rodriguez Dubra C, Bolondi A, Cacciato C, Cobo ER, Perez S, Odeon A, Cipolla A, BonDurant R
Heifers immunized with whole-cell and membrane vaccines against Tritrichomonas foetus and naturally challenged with an infected bull
Veterinary Parasitology, 2002
Cobo ER, Cano D, Rossetti O, Campero C
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Nuevos aspectos inmunológicos y vacunales de la tricomoniasis bovina
Revista de Medicina Veterinaria, 2002
Cobo ER, Campero C
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Experimental infection with Tritrichomonas suis in heifers
Veterinary Parasitology, 2001
Cobo ER, Cano D, Campero C
Riesgo y control de Campylobacter fetus en el semen bovino usado para inseminación artificial en Argentina
Therios, 2000
Cobo ER
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Aislamiento de Brucella ovis del semen de carneros seropositivos a la prueba de ELISA y con clínica genital normal
Revista Argentina de Microbiología, 1999
Paolicchi F, Cipolla A, Vagnoni L, Cobo ER, Vagnozzi A, Ramondino R, Silva Paulo P, Vigliocco A
Reporte de dos casos de feocromocitoma en ovejas adultas
Veterinaria Argentina, 1998
Campero C, Cobo ER, Vagnoni L, Vagnozzi A
Book Chapters
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Antimicrobial peptides in gastrointestinal disease.
Chapter 7:"Host defense peptides as innate immunomodulators in the pathogenesis of colitis".
Elsevier B978-0-12-814319.
Holani R, Marin M, Kastelic J, Cobo ER (2018)
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Frontiers in Parasitology (Volume 2). Water-borne protozoa in humans.
Chapter 5: Entamoeba histolytica and other pathogenic intestinal amoebae: 103-123. ISBN: 978-1-68108-434-3, ISSN: 2542-4211. Edited by Fabrizio Bruschi (Univ. di Pisa, Italy). Published by Bentham Science Publishers, Sharjah, United Arab Emirates.
Cobo ER; Chadee K (2017)
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