Every innate immune reaction is a lesson on how to survive infections without dying in the attempt
Publications
2022
2021
2020
2019
2018
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2016
2015
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1998
Journal Articles
Cathelicidins Induce Toll-Interacting Protein Synthesis to Prevent Apoptosis in Colonic Epithelium
Journal of Innate Immunity , Sept 2022
Ravi Holani, Chathurika Rathnayaka, Graham A D Blyth, Anshu Babbar, Priyoshi Lahiri, Daniel Young, Antoine Dufour, Morley D Hollenberg, Derek M McKay, Eduardo R Cobo
Systemic murine cathelicidin CRAMP safely attenuated colonic neutrophil infiltration in pigs
Vet Immunol Immunopathol , July 2022
Cristina C Fodor , Robert McCorkell , Greg Muench , Eduardo R Cobo
Sequence edition of single domains modulates the final immune and antimicrobial potential of a new generation of multidomain recombinant proteins
Ramon Roca-Pinilla, Ravi Holani, Adrià López-Cano, Cristina Saubi, Ricardo Baltà-Foix, Eduardo R. Cobo, Elena Garcia-Fruitós, and Anna Arís
Effects of different culture media on growth of Treponema spp. isolated from digital dermatitis
Anaerobe, Feb 2021
Rakel Arrazuria, Ben Caddey, Eduardo R Cobo, Herman W Barkema, Jeroen De Buck
Peritoneal macrophages are impaired in cathelicidin-deficient mice systemically challenged with Escherichia coli
Cell and Tissue Research, March 2021
Emily Boucher, Luke Brown, Priyoshi Lahiri, Eduardo R Cobo
Early immune innate hallmarks and microbiome changes across the gut during Escherichia coli O157: H7 infection in cattle
Scientific Reports, Dec 2020
Mariano Larzábal, Wanderson Marques Da Silva, Anmol Multani, Lucas E Vagnoni, Dadin P Moore, Maia S Marin, Nahuel A Riviere, Fernando O Delgado, Daniel A Vilte, Matias Romero Victorica, Tao Ma, Luo Le Guan, Paola Talia, Angel Cataldi, Eduardo R Cobo.
Treponema spp. Isolated from Bovine Digital Dermatitis Display Different Pathogenicity in a Murine Abscess Model
Microorganisms, Sep 2020
Rakel Arrazuria, Cameron G Knight, Priyoshi Lahiri, Eduardo R Cobo, Herman W Barkema, Jeroen De Buck.
PMID: 33007829 DOI: 10.3390/microorganisms8101507
Delayed-type hypersensitivity skin test against Neospora caninum in heifers with undetectable specific antibodies
Comparative Immunology, Microbiology and Infectious Diseases Volume 72, October 2020
Fiorani F., Hecker Y.P., Cirone K.M., Armendano J.I. Gual I., Campero L.M., Wilkowsky S.E., Cobo E. R., Corva P.M., Morrell E.L., Cantón G.J., Moore D.P.
Science Direct https://doi.org/10.1016/j.cimid.2020.101522
Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production.
Gut Microbes. 13 July 2020
Ravi Holani, Anshu Babbar, Graham A. D. Blyth, Fernando Lopes, Humberto Jijon, Derek M. McKay, Morley D. Hollenberg & Eduardo R. Cobo
Taylor & Francis Online published Open Access.
The Network of Colonic Host Defense Peptides as an Innate Immune Defense Against Enteropathogenic Bacteria.
Frontiers Immunology. 20 May 2020
Graham A. D. Blyth, Liam Connors, Cristina Fodor and Eduardo R. Cobo (2020)
Cathelicidins mitigate Staphylococcus aureus mastitis and reduce bacterial invasion in murine mammary epithelium.
Infection and Immunity. 2020 Apr 27. pii: IAI.00230-20. doi: 10.1128/IAI.00230-20.
Cavalcante PA, Knight CG, Tan YL, Monteiro APA, Barkema HW, Cobo ER (2020)
Klebsiella pneumoniae isolated from bovine mastitis is cytopathogenic for bovine mammary epithelial cells.
J Dairy Science. Feb 6. pii: S0022-0302(20)30086-2. doi: 10.3168/jds.2019-17458.
Cheng J, Zhang J, Han B, Barkema HW, Cobo ER, Kastelic JP, Zhou M, Shi Y, Wang J, Yang R, Gao J (2020)
Prototheca zopfii genotype II induces mitochondrial apoptosis in models of bovine mastitis.
Sci Rep. 10(1):698. doi: 10.1038/s41598-020-57645-z.
Shahid M, Cobo ER, Chen L, Cavalcante PA, Barkema HW, Gao J, Xu S, Liu Y, Knight CG, Kastelic JP, Han B (2020)
Synthetic cathelicidin LL-37 reduces Mycobacterium avium subsp. paratuberculosis internalization and pro-inflammatory cytokines in macrophages.
Cell Tissue Res. 2020 Jan; 379(1):207-217. doi: 10.1007/s00441-019-03098-4. Epub 2019 Sep 2.
Cirone KM, Lahiri P, Holani R, Tan YL, Arrazuria R, De Buck J, Barkema HW, Cobo ER (2020)
Oxytetracycline reduces inflammation and treponeme burden whereas vitamin D3 promotes β-defensin expression in bovine infectious digital dermatitis.
Cell Tissue Res. 2020 Feb; 379(2):337-348. doi: 10.1007/s00441-019-03082-y. Epub 2019 Aug 13.
Watts KM, Lahiri P, Arrazuria R, De Buck J, Knight CG, Orsel K, Barkema HW, Cobo ER (2020)
Adherent/invasive capacities of bovine-associated Aerococcus viridans contribute to pathogenesis of acute mastitis in a murine model.
Vet Microbiol. 2019 Mar; 230:202-211. doi: 10.1016/j.vetmic.2019.02.016. Epub 2019 Feb 8.
Liu G, Yin J, Han B, Barkema HW, Shahid M, De Buck J, Cobo ER, Kastelic JP, Gao J (2019)
Human cathelicidin improves colonic epithelial defenses against Salmonella typhimurium by modulating bacterial invasion, TLR4 and pro-inflammatory cytokines.
Cell Tissue Res. 2019 Jun; 376(3):433-442. doi: 10.1007/s00441-018-02984-7. Epub 2019 Feb 20.
Marin M, Holani R, Blyth GAD, Drouin D, Odeón A, Cobo ER (2019)
Molecular epidemiology and distribution of antimicrobial resistance genes of Staphylococcus species isolated from Chinese dairy cows with clinical mastitis.
J Dairy Sci. 2019 Feb; 102(2):1571-1583. doi: 10.3168/jds.2018-15136. Epub 2018 Dec 24.
Qu Y, Zhao H, Nobrega DB, Cobo ER, Han B, Zhao Z, Li S, Li M, Barkema HW, Gao J (2019)
Correction for Cobo et al., "Entamoeba histolytica Alters Ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency".
Infect Immun. 2018 Sep 21; 86(10). pii: e00564-18. doi: 10.1128/IAI.00564-18.
Cobo ER, Holani R, Moreau F, Nakamura K, Ayabe T, Mastroianni JR, Eriguchi Y, Ouellette A, Chadee K (2018)
A Differential Innate Immune Response in Active and Chronic Stages of Bovine Infectious Digital Dermatitis.
Front Microbiol. 2018 Jul 19; 9:1586. doi: 10.3389/fmicb.2018.01586. eCollection 2018.
Watts KM, Fodor C, Beninger C, Lahiri P, Arrazuria R, De Buck J, Knight CG, Orsel K, Barkema HW, Cobo ER (2018)
Entamoeba histolytica alters ileal Paneth cell functions in intact and Muc2 mucin deficiency.
Infection and Immunity (IAI00208-18). “Spotlight” as research article of significant interest from the current issue.
Cobo ER., Holani R, Moreau F, Nakamura K, Ayabe T, Mastroianni J, Ouellette A, Chadee K (2018)
Host defense cathelicidins in cattle: types, production, bioactive functions and potential therapeutic and diagnostic applications.
International Journal Antimicrobial Agents, pii: S0924-8579(18)30044-X. doi: 10.1016/j.ijantimicag.2018.02.006.
Young-Speirs M., Drouin D., Cavalcante P.A., Barkema H.W., Cobo ER (2018)
Cathelicidin modulates synthesis of Toll-like receptors (TLRs) 4 and 9 in colonic epithelium.
Molecular Immunology Oct 4; 91: 249-258. doi: 10.1016.
Marin M.; Holani R.; Shah C.B.; Odeon A.; Cobo E.R. (2017)
Toll-like receptors 3, 7 and 8 are upregulated in the placental caruncle and fetal spleen of Nesopora caninum experimentally infected cattle.
Veterinary Parasitology, Mar 15; 236:58-61. doi: 10.1016.
Marin M.; Hecker Y.; Quintana S.; Perez S.; Leunda M.; Canton G.; Cobo E.R.; Moore D.; Odeon A. (2017)
MUC2 mucin and butyrate contribute to the synthesis of the antimicrobial peptide cathelicidin in response to Entamoeba histolytica and dextran sodium sulfate- induced colitis.
Infection and Immunity, 23;85(3). pii: e00905-16. doi: 10.1128/IAI.00905-16.
Cobo E.R.; Kissoon-Singh V.; Moreau, F.; Holani R.; Chadee K. (2017)
Proline-arginine rich (PR-39) cathelicidin: Structure, expression and functional implication in intestinal health.
Comparative Immunology Microbiology Infectious Diseases, 49: 95-101.
Holani R.; Shah C.; Haji Q., Inglis G.D., Uwiera R.R.; Cobo E.R. (2016)
A review of sexually transmitted bovine trichomoniasis and campylobacteriosis affecting cattle reproductive health.
Theriogenology 85 (5): 781-91.
Michi A, Favetto H, Kastelic J, Cobo E. (2016)
Colonic MUC2 mucin regulates the expression and antimicrobial activity of defensin 2.
Mucosal Immunology 8(16): 1360-72.2.
Cobo E, Kissoon-Singh V, Moreau F, Chadee K. (2015)
Expanded therapeutic potential in broad activity space of structurally diverse next-generation 5- nitroimidazole antimicrobials.
Proceeding of the National Academy of Sciences of the United States of America (PNAS) 110(43): 17564-17569.
Miyamoto Y, Kalisiak J, Korthals K, Tineke S, Young Cheung D, Lozano R, Cobo E, Upcroft P, Upcroft J, Gillin F, Fokin V, Sharpless B, Eckmann L. (2013).
Antimicrobial human defensins in the colon and their role in infectious and non-infectious diseases.
Pathogens 2(1): 177-192.
Cobo E, Chadee K. (2013)
A high throughput drug screen for Entamoeba histolytica identifies a new lead and target.
Nature Medicine 18(6): 956-960.
Debnath A, Parsonage D, Andrade R, He C, Cobo E, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez M, Gunatilleke S, Barrios A, Arkin M, Poole L, McKerrow J, Reed S. (2012)
Effect of vinyl sulfone inhibitors of cysteine proteinases on Tritrichomonas foetus infection.
International Journal of Antimicrobial Agents 39(3): 259-262.
Cobo E, Reed S, Corbeil L. (2012)
Entamoeba histolytica induces intestinal cathelicidins but is resistant to cathelicidin-mediated killing.
Infection and Immunity 80(1): 143-149.
Cobo E, He C, Hirata K, Hwang G, Tran U, Eckmann L, Gallo R, Reed S. (2012)
Murine models of vaginal trichomonad infections.
American Journal of Tropical Medicine and Hygiene 85(4): 667-673.
Cobo E, Eckmann L, Corbeil L. (2011)
Immunity to infections in the lower genital tract of bulls.
Journal of Reproductive Immunology 89(1): 55-61.
Cobo E, Corbeil L, BonDurant R. (2011)
A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target.
Journal of Biological Chemistry 285(24): 18516-18527.
He C, Nora G, Scheider E, Kerr I, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd S, Hruz P, Cobo E, Le C, Liu W, Eckmann L, Dorrestein P, Houpt E, Brinen L, Craik C, Roush W, McKerrow J, Reed S. (2010)
Preputial cellular and antibody responses of bulls vaccinated and/or challenged with Tritrichomonas foetus.
Vaccine 11(28): 361-370.
Cobo E, Corbeil L, Gerswhin L, BonDurant R. (2009)
Comparative histopathology and antibody responses in virgin heifers experimentally infected with non-Tritrichomonas foetus trichomonads or Tritrichomonas foetus.
Veterinary Parasitology 151, 2-4: 170-180.
Agnew D.; Munson L.; Cobo E.R.; Olesen D.; Corbeil L.; BonDurant R. (2008)
Tetratrichomonas spp. and Pentatrichomonas hominis are not persistently detectable after intravaginal inoculation of estrous heifers.
Veterinary Parasitology 150, 1-2: 18-26.
Cobo E.R.; Corbeil L.; Agnew D.; VanHoosear K.; Friend A.; Olesen D.; BonDurant R. (2007)
Sensitivity and specificity of culture and PCR applied directly on smegma samples of bulls for testing of Tritrichomonas foetus.
Theriogenology 68, 6: 853-860.
Cobo E.R.; Favetto P.; Lane V.; Friend A.; VanHoosear K.; Mitchell J.; BonDurant R. (2007)
Bayesian estimation of Tritrichomonas foetus diagnostic test sensitivity and specificity in range beef bulls.
Veterinary Parasitology 142, 1-2: 159-162.
Perez A.; Cobo E.R.; Martinez A.; Campero C.; Spath E. (2006)
Tritrichomonas foetus: patogénesis de la mortalidad embrionaria/fetal, caracterización de antígenos vacunales y respuesta inmune inducida.
Revista de Medicina Veterinaria 87: 47-56.
Campero C.; Cobo E.R. (2006)
Immunization in heifers with dual vaccines containing Tritrichomonas foetus and Campylobacter fetus antigens using systemic and mucosal routes.
Theriogenology 62, 8: 1367-1382.
Cobo E.R.; Morsella C.; Cano D.; Cipolla A.; Campero C. (2004)
Lectin binding pattern and immunohistochemical antigen detection in the genitalia of Tritrichomonas foetus-infected heifers.
Journal of Comparative Pathology 131, 2-3: 127-134.
Cobo E.R.; Campero, C.; Gimeno E.; Barbeito C. (2004)
Failure to establish infection with Tetratrichomonads spp. in the reproductive tracts of heifers and bulls.
Veterinary Parasitology 120: 145-150.
Cobo E.R.; Canton G.; Morrell E.; Cano D.; Campero C. (2004)
Ultrastructural study of a tetratrichomonad species isolated from preputial smegma of virgin bulls.
Veterinary Parasitology 117: 195-211.
Cobo E.R.; Campero C.; Mariante R.; Benchimol M. (2003)
Effect of two commercial vaccines to Campylobacter fetus subspecies on heifers naturally challenged.
Journal Veterinary Medicine 50, 2: 75-80.
Cobo E.R.; Cipolla A.; Morsella C.; Cano D.; Campero C. (2003)
Two-step (culture and PCR) diagnostic approach for differentiation of non-T. foetus trichomonads from genitalia of virgin beef bulls in Argentina.
Veterinary Parasitology 112, 3: 167-175.
Campero C.; Rodriguez Dubra C.; Bolondi A.; Cacciato C.; Cobo E.R.; Perez S.; Odeon A.; Cipolla A.; BonDurant R. (2003)
Heifers immunized with whole-cell and membrane vaccines against Tritrichomonas foetus and naturally challenged with an infected bull.
Veterinary Parasitology 109: 169-184.
Cobo E.R.; Cano D.; Rossetti O.; Campero C. (2002)
Nuevos aspectos inmunológicos y vacunales de la tricomoniasis bovina.
Revista de Medicina Veterinaria 83, 5: 203-208.
Cobo E.R.; Campero C. (2002)
Experimental infection with Tritrichomonas suis in heifers.
Veterinary Parasitology 99, 1: 73-78.
Cobo E.R., Cano D.; Campero C. (2001)
Riesgo y control de Campylobacter fetus en el semen bovino usado para inseminación artificial en Argentina.
Therios 29, 153: 102-107.
Cobo E.R. (2000)
Aislamiento de Brucella ovis del semen de carneros seropositivos a la prueba de ELISA y con clínica genital normal.
Revista Argentina de Microbiología 31, 1: 40-43.
Paolicchi F.; Cipolla A.; Vagnoni L.; Cobo E.R.; Vagnozzi A; Ramondino R.; Silva Paulo P.; Vigliocco A. (1999)
Reporte de dos casos de feocromocitoma en ovejas adultas.
Veterinaria Argentina 143: 180-183.
Campero C.; Cobo E.R.; Vagnoni L.; Vagnozzi A. (1998).
Book Chapters
Antimicrobial peptides in gastrointestinal disease.
Chapter 7:"Host defense peptides as innate immunomodulators in the pathogenesis of colitis".
Elsevier B978-0-12-814319.
Holani R, Marin M, Kastelic J, Cobo ER (2018)
Frontiers in Parasitology (Volume 2). Water-borne protozoa in humans.
Chapter 5: Entamoeba histolytica and other pathogenic intestinal amoebae: 103-123. ISBN: 978-1-68108-434-3, ISSN: 2542-4211. Edited by Fabrizio Bruschi (Univ. di Pisa, Italy). Published by Bentham Science Publishers, Sharjah, United Arab Emirates.
Cobo ER; Chadee K (2017)