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Journal Articles

Proinflammatory CD14highCD16low monocytes/macrophages prevail in Treponema phagedenis- associated bovine digital dermatitis formation

Infection Immunity, 2024

Lahiri P, Arrazuria R, Tan YL, DeBuck J, Hollenberg M, Orsel K, CoboER

PMID: 38189287

Streptococcus uberis induced expressions of pro-inflammatory IL-6, TNF-α, and IFN-γ in bovine mammary epithelial cells associated with inhibited autophagy and autophagy flux formation

Microbial Pathogenesis, 2023

Khan SYang J, Cobo ER, Wang YXu MWang T, Shi YLiu GHan B

PMID: 37499842

Host innate immune responses and microbiome profile of neonatal calves challenged with Cryptosporidium parvum and the effect of bovine colostrum supplementation

Frontiers in Cellular and Infection Microbiology, 2023

Gamsjäger L, Cirone KMSchluessel SCampsall MHerik ALahiri P Young DDufour ASapountzis POtani SGomez DEWindeyer MCCobo ER 

PMID: 37207189

Colonic innate immune defenses and microbiota alterations in acute swine dysentery

Microbial Pathogenesis, 2022

Fodor CC, Fouhse JDrouin DMa TWilling BPGuan LLCobo ER

PMID: 36371065

Assessment of microRNA profiles in small extracellular vesicles isolated from bovine colostrum with different immunoglobulin G concentrations

Journal Dairy Science (JDS) Communication, 2022

Ma T, Li WChen Y, Cobo ER, Windeyer CGamsjäger L, Diao Q, Tu YGuan LL

PMID: 36340908

Cathelicidins induce Toll-Interacting protein synthesis to prevent apoptosis in colonic epithelium

Journal of Innate Immunity , 2022

Holani RRathnayaka CBlyth GADBabbar ALahiri PYoung DDufour AHollenberg MDMcKay DMCobo ER 

PMID: 36116427

Interleukin-4 programmed macrophages suppress colitis and do not enhance infectious-colitis, ionflammation-associated colon cancer or airway hypersensitivityepithelium

Frontiers in Immunology, 2021

Callejas BEBlyth GAD, Jendzjowsky N, Wang A, Babbar AKoro K, Wilson RJA, Kelly MMCobo ER, McKay DM

PMID: 34691050

Systemic murine cathelicidin CRAMP safely attenuated colonic neutrophil infiltration in pigs

Veterinary Immunology and Immunopathology, 2022

Fodor CCMcCorkell RMuench G, Cobo ER 

PMID: 35640361

Sequence edition of single domains modulates the final immune and antimicrobial potential of a new generation of multidomain recombinant proteins

Scientific Report, 2021

Roca-Pinilla RHolani RLópez-Cano ASaubi CBaltà-Foix RCobo ERGarcia-Fruitós E, Arís A

PMID: 34893661

Effects of different culture media on growth of Treponema spp. isolated from digital dermatitis

Anaerobe, 2021

Arrazuria RCaddey BCobo ERBarkema HWDe Buck J

PMID: 33596466

Peritoneal macrophages are impaired in cathelicidin-deficient mice systemically challenged with Escherichia coli

Cell and Tissue Research, 2021

Boucher EBrown LLahiri PCobo ER

PMID: 33496883

Early immune innate hallmarks and microbiome changes across the gut during Escherichia coli O157: H7 infection in cattle

Scientific Reports, 2020

Larzábal MMarques Da Silva WMultani AVagnoni LEMoore DPMarin MSRiviere NADelgado FOVilte DARomero Victorica MMa TGuan LLTalia PCataldi ACobo ER.

PMID: 33299023

Treponema spp. isolated from bovine digital dermatitis display different pathogenicity in a murine abscess model

Microorganisms​, 2020

Arrazuria RKnight CGLahiri PCobo ERBarkema HWDe Buck J

PMID: 33007829

Delayed-type hypersensitivity skin test against Neospora caninum in heifers with undetectable specific antibodies

Comparative Immunology, Microbiology and Infectious Diseases, 2020

Fiorani F, Hecker YP, Cirone KM, Armendano JI, Gual I, Campero LM, Wilkowsky SE, Cobo ER, Corva PM, Morrell EL, Cantón GJ, Moore DP

PMID: 32739729

Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production

Gut Microbes, 2020

Holani R, Babbar A, Blyth GAD, Lopes F, Jijon H, McKay DM, Hollenberg MD, Cobo ER 

PMID: 32658599

The network of colonic host defense peptides as an innate immune defense against enteropathogenic bacteria

Frontiers in Immunology, 2020 

Blyth GAD, Connors L, Fodor CC, Cobo ER

PMID: 32508838

Cathelicidins mitigate Staphylococcus aureus mastitis and reduce bacterial invasion in murine mammary epithelium

Infection and Immunity, 2020

Cavalcante PA, Knight CG, Tan YL, Monteiro APA, Barkema HW, Cobo ER

PMID: 32341117

Klebsiella pneumoniae isolated from bovine mastitis is cytopathogenic for bovine mammary epithelial cells

J Dairy Science, 2020

Cheng J, Zhang J, Han B, Barkema HW, Cobo ER, Kastelic JP, Zhou M, Shi Y, Wang J, Yang R, Gao J 

PMID: 32037181


Prototheca zopfii genotype II induces mitochondrial apoptosis in models of bovine mastitis

Scientific Reports, 2020

Shahid M, Cobo ER, Chen L, Cavalcante PA, Barkema HW, Gao J, Xu S, Liu Y, Knight CG, Kastelic JP, Han B

PMID: 31959834

Synthetic cathelicidin LL-37 reduces Mycobacterium avium subsp. paratuberculosis internalization and pro-inflammatory cytokines in macrophages 

Cell Tissue Research, 2020

Cirone KM, Lahiri P, Holani R, Tan YL, Arrazuria R, De Buck J, Barkema HW, Cobo ER

PMID: 31478135


Oxytetracycline reduces inflammation and treponeme burden whereas vitamin D3 promotes β-defensin expression in bovine infectious digital dermatitis

Cell Tissue Research, 2020

Watts KM, Lahiri P, Arrazuria R, De Buck J, Knight CG, Orsel K, Barkema HW, Cobo ER

PMID: 31410630

Adherent/invasive capacities of bovine-associated Aerococcus viridans contribute to pathogenesis of acute mastitis in a murine model

Veterinary Microbiology, 2019

Liu G, Yin J, Han B, Barkema HW, Shahid M, De Buck J, Cobo ER, Kastelic JP, Gao J

PMID: 30827389


Human cathelicidin improves colonic epithelial defenses against Salmonella typhimurium by modulating bacterial invasion, TLR4 and pro-inflammatory cytokines

Cell Tissue Research, 2019

Marin M, Holani R, Blyth GAD, Drouin D, Odeón A, Cobo ER

PMID: 30788579


Molecular epidemiology and distribution of antimicrobial resistance genes of Staphylococcus species isolated from Chinese dairy cows with clinical mastitis

Journal Dairy Science, 2019

Qu Y, Zhao H, Nobrega DB, Cobo ER, Han B, Zhao Z, Li S, Li M, Barkema HW, Gao J

PMID: 30591326


A differential innate immune response in active and chronic stages of bovine infectious digital dermatitis

Frontiers in Microbiolology, 2018

Watts KM, Fodor C, Beninger C, Lahiri P, Arrazuria R, De Buck J, Knight CG, Orsel K, Barkema HW, Cobo ER

PMID: 30072966


Entamoeba histolytica alters ileal Paneth cell functions in intact and Muc2 mucin deficiency

Infection and Immunity, 2018. “Spotlight” as research article of significant interest from the current issue. 

Cobo ER, Holani R, Moreau F, Nakamura K, Ayabe T, Mastroianni J, Ouellette A, Chadee K

PMID: 29685982


Host defense cathelicidins in cattle: types, production, bioactive functions and potential therapeutic and diagnostic applications

International Journal Antimicrobial Agents, 2018 

Young-Speirs M, Drouin D, Cavalcante PA, Barkema HW, Cobo ER

PMID: 29476808


Cathelicidin modulates synthesis of Toll-like receptors (TLRs) 4 and 9 in colonic epithelium

Molecular Immunology, 2017

Marin M, Holani R, Shah CB, Odeon A, Cobo ER

PMID: 28988039


Toll-like receptors 3, 7 and 8 are upregulated in the placental caruncle and fetal spleen of Nesopora caninum experimentally infected cattle

Veterinary Parasitology, 2017

Marin M, Hecker Y, Quintana S, Perez S, Leunda M, Canton G, Cobo ER, Moore D, Odeon A

PMID: 28288766


MUC2 mucin and butyrate contribute to the synthesis of the antimicrobial peptide cathelicidin in response to Entamoeba histolytica and dextran sodium sulfate- induced colitis

Infection and Immunity,  2017

Cobo ER, Kissoon-Singh V, Moreau F, Holani R, Chadee K

PMID: 28069814


Proline-arginine rich (PR-39) cathelicidin: Structure, expression and functional implication in intestinal health

Comparative Immunology Microbiology Infectious Diseases, 2016

Holani R, Shah C, Haji Q, Inglis GD, Uwiera RR, Cobo ER

PMID: 27865272


A review of sexually transmitted bovine trichomoniasis and campylobacteriosis affecting cattle reproductive health

Theriogenology, 2016

Michi A, Favetto H, Kastelic J, Cobo ER

PMID: 26679515


Colonic MUC2 mucin regulates the expression and antimicrobial activity of β-defensin 2

Mucosal Immunology, 2015

Cobo E, Kissoon-Singh V, Moreau F, Chadee K

PMID: 25921338


Expanded therapeutic potential in broad activity space of structurally diverse next-generation 5- nitroimidazole antimicrobials

Proceeding of the National Academy of Sciences of the United States of America (PNAS), 2013

Miyamoto Y, Kalisiak J, Korthals K, Tineke S, Young Cheung D, Lozano R, Cobo ER, Upcroft P, Upcroft J, Gillin F, Fokin V, Sharpless B, Eckmann L

PMID: 24101497


Antimicrobial human defensins in the colon and their role in infectious and non-infectious diseases 

Pathogens, 2013 

Cobo ER, Chadee K

PMID: 25436887


A high throughput drug screen for Entamoeba histolytica identifies a new lead and target

Nature Medicine, 2012

Debnath A, Parsonage D, Andrade R, He C, Cobo ER, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez M, Gunatilleke S, Barrios A, Arkin M, Poole L, McKerrow J, Reed S

PMID: 22610278


Effect of vinyl sulfone inhibitors of cysteine proteinases on Tritrichomonas foetus infection

International Journal of Antimicrobial Agents, 2012

Cobo ER, Reed S, Corbeil L

PMID: 22104282


Entamoeba histolytica induces intestinal cathelicidins but is resistant to cathelicidin-mediated killing

Infection and Immunity, 2012

Cobo ER, He C, Hirata K, Hwang G, Tran U, Eckmann L, Gallo R, Reed S

PMID: 22083705


Murine models of vaginal trichomonad infections

American Journal of Tropical Medicine and Hygiene, 2011

Cobo ER, Eckmann L, Corbeil L

PMID: 21976570


Immunity to infections in the lower genital tract of bulls

Journal of Reproductive Immunology, 2011

Cobo ER, Corbeil L, BonDurant R

PMID: 21474188


A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target

Journal of Biological Chemistry, 2010

He C, Nora G, Scheider E, Kerr I, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd S, Hruz P, Cobo E, Le C, Liu W, Eckmann L, Dorrestein P, Houpt E, Brinen L, Craik C, Roush W, McKerrow J, Reed S

PMID: 20378535


Preputial cellular and antibody responses of bulls vaccinated and/or challenged with Tritrichomonas foetus

Vaccine, 2019

Cobo ER, Corbeil L, Gerswhin L, BonDurant R

PMID: 19879225


Comparative histopathology and antibody responses in virgin heifers experimentally infected with non-Tritrichomonas foetus trichomonads or Tritrichomonas foetus

Veterinary Parasitology, 2018

Agnew D, Munson L, Cobo ER, Olesen D, Corbeil L, BonDurant R

PMID: 18078717


Tetratrichomonas spp. and Pentatrichomonas hominis are not persistently detectable after intravaginal inoculation of estrous heifers

Veterinary Parasitology, 2015

Cobo ER, Corbeil L, Agnew D, VanHoosear K, Friend A, Olesen D, BonDurant R

PMID: 17950533


Sensitivity and specificity of culture and PCR applied directly on smegma samples of bulls for testing of Tritrichomonas foetus

Theriogenology, 2007

Cobo ER, Favetto P, Lane V, Friend A, VanHoosear K, Mitchell J, BonDurant R

PMID: 17681370


Bayesian estimation of Tritrichomonas foetus diagnostic test sensitivity and specificity in range beef bulls

Veterinary Parasitology, 2006

Perez A, Cobo ER, Martinez A, Campero C, Spath E

PMID: 16876951


Tritrichomonas foetus: patogénesis de la mortalidad embrionaria/fetal, caracterización de antígenos vacunales y respuesta inmune inducida

Revista de Medicina Veterinaria, 2006

Campero C, Cobo ER


Immunization in heifers with dual vaccines containing Tritrichomonas foetus and Campylobacter fetus antigens using systemic and mucosal routes

Theriogenology, 2004

Cobo ER, Morsella C, Cano D, Cipolla A, Campero C

PMID: 15451246


Lectin binding pattern and immunohistochemical antigen detection in the genitalia of Tritrichomonas foetus-infected heifers

Journal of Comparative Pathology, 2004

Cobo ER, Campero C, Gimeno E, Barbeito C

PMID: 15276852


Failure to establish infection with Tetratrichomonads spp. in the reproductive tracts of heifers and bulls

Veterinary Parasitology, 2004

Cobo ER, Canton G, Morrell E, Cano D, Campero C

PMID: 15019152


Ultrastructural study of a tetratrichomonad species isolated from preputial smegma of virgin bulls

Veterinary Parasitology, 2003

Cobo ER, Campero C, Mariante R, Benchimol M

PMID: 14630428


Effect of two commercial vaccines to Campylobacter fetus subspecies on heifers naturally challenged

Journal Veterinary Medicine, 2003

Cobo ER, Cipolla A, Morsella C, Cano D, Campero C

PMID: 12675898


Two-step (culture and PCR) diagnostic approach for differentiation of non-T. foetus trichomonads from genitalia of virgin beef bulls in Argentina

Veterinary Parasitology, 2003

Campero C, Rodriguez Dubra C, Bolondi A, Cacciato C, Cobo ER, Perez S, Odeon A, Cipolla A, BonDurant R

PMID: 12591192


Heifers immunized with whole-cell and membrane vaccines against Tritrichomonas foetus and naturally challenged with an infected bull

Veterinary Parasitology, 2002

Cobo ER, Cano D, Rossetti O, Campero C

PMID: 12423930

Nuevos aspectos inmunológicos y vacunales de la tricomoniasis bovina

Revista de Medicina Veterinaria, 2002

Cobo ER, Campero C

Experimental infection with Tritrichomonas suis in heifers

Veterinary Parasitology, 2001

Cobo ER, Cano D, Campero C

PMID: 11445157


Riesgo y control de Campylobacter fetus en el semen bovino usado para inseminación artificial en Argentina

Therios, 2000

Cobo ER

Aislamiento de Brucella ovis del semen de carneros seropositivos a la prueba de ELISA y con clínica genital normal

Revista Argentina de Microbiología, 1999 

Paolicchi F, Cipolla A, Vagnoni L, Cobo ER, Vagnozzi A, Ramondino R, Silva Paulo P, Vigliocco A

PMID: 10509410


Reporte de dos casos de feocromocitoma en ovejas adultas

Veterinaria Argentina, 1998

Campero C, Cobo ER, Vagnoni L, Vagnozzi A


Book Chapters

Antimicrobial peptides in gastrointestinal disease.

Chapter 7:"Host defense peptides as innate immunomodulators in the pathogenesis of colitis".

Elsevier B978-0-12-814319.

Holani R, Marin M, Kastelic J, Cobo ER (2018)

Frontiers in Parasitology (Volume 2). Water-borne protozoa in humans.

Chapter 5: Entamoeba histolytica and other pathogenic intestinal amoebae: 103-123. ISBN: 978-1-68108-434-3, ISSN: 2542-4211. Edited by Fabrizio Bruschi (Univ. di Pisa, Italy). Published by Bentham Science Publishers, Sharjah, United Arab Emirates.

Cobo ER; Chadee K (2017)

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