The  small  big effectors in

epithelial defenses

Welcome to Cobo Lab

OUR FOCUS

We investigate the biological function of small cationic host defense peptides (cathelicidins and defensins) secreted by white blood cells and the epithelial cells in mammals.

 

The main focus is to discover the underlying mechanisms of cathelicidins and defensins which show to have an important beneficial role in tissue homeostasis, including regulation of harmful inflammation and control of microbial pathogens.

 

The goal is to advance cathelicidins and defensins (either synthetic derivatives or induction of endogenous production) as natural, efficacious and cost-effective alternatives to current treatments that could reduce the use of conventional antibiotics. This innovation will also benefit the community by reducing economic losses in animal production, improving animal welfare and promoting an environmentally friendly public image for the industry.

OUR LAB

Selected Publications

Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production.

Gut Microbes. July 2020

Cathelicidins mitigate Staphylococcus aureus mastitis and reduce bacterial invasion in murine mammary epithelium.

Infection and Immunity. 2020

 

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target.

Nature Medicine. 2012

 

Colonic MUC2 mucin regulates the expression and antimicrobial activity of β-defensin 2.

Mucosal Immunology. 2015

Human Cathelicidins Contribute Differently to Hallmarks of Mastitis Induced by Pathogenic Prototheca bovis Algae.

Frontiers in Cellular and Infection microbiology. 2020

 

Entamoeba histolytica Alters Ileal Paneth Cell Functions

in Intact and Muc2 Mucin Deficiency.

Infection and Immunity. 2018 

 

MUC2 Mucin and Butyrate Contribute to the Synthesis of the Antimicrobial Peptide Cathelicidin in Response to Entamoeba histolytica- and Dextran Sodium Sulfate-Induced Colitis.

Infection and Immunity. 2017 

Funding Agencies

Thank you for your interest and all the support! We are glad to hear from you.

Contact

Email: ecobo@ucalgary.ca

Phone: (403) 210-7247

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© 2020 by Yi Lin Tan, MSc. Proudly created with Wix.com