top of page
Pipetting Samples

The small big effectors in

epithelial defenses

Welcome to Cobo Lab



We investigate the biological function of small cationic host defense peptides (cathelicidins and defensins) secreted by white blood cells and the epithelial cells in mammals.


The main focus is to discover the underlying mechanisms of cathelicidins and defensins which show to have an important beneficial role in tissue homeostasis, including regulation of harmful inflammation and control of microbial pathogens.


The goal is to advance cathelicidins and defensins (either synthetic derivatives or induction of endogenous production) as natural, efficacious and cost-effective alternatives to current treatments that could reduce the use of conventional antibiotics. This innovation will also benefit the community by reducing economic losses in animal production, improving animal welfare and promoting an environmentally friendly public image for the industry.

Slide to see our projects


Selected Publications

Screen Shot 2020-04-03 at 8.41.55 AM.png

Host innate immune responses and microbiome profile of neonatal calves challenged with Cryptosporidium parvum and the effect of bovine colostrum supplementation

Frontiers in Cellular and Infection Microbiology. 2023

Cathelicidins induce Toll-Interacting protein synthesis to prevent apoptosis in colonic epithelium

Journal of Innate Immunity. 2022

Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production

Gut Microbes. 2020

Cathelicidins mitigate Staphylococcus aureus mastitis and reduce bacterial invasion in murine mammary epithelium

Infection and Immunity. 2020


Entamoeba histolytica alters ileal Paneth cell functions

in intact and Muc2 mucin deficiency

Infection and Immunity. 2018


MUC2 mucin and butyrate contribute to the synthesis of the antimicrobial peptide cathelicidin in response to Entamoeba histolytica- and dextran sodium sulfate-induced colitis

Infection and Immunity. 2017

Colonic MUC2 mucin regulates the expression and antimicrobial activity of β-defensin 2

Mucosal Immunology. 2015

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

Nature Medicine. 2012

Funding Agencies


Thank you for your interest and all the support!

bottom of page